Publications
Augmentation of arginase 1 expression by exposure to air pollution exacerbates the airways hyperresponsiveness in murine models of asthma
North ML, Amatullah H, Khanna N, Urch B, Grasemann H, Silverman F, Scott JA. Respir Res. 2011 Feb 3;12(1):19. doi: 10.1186/1465-9921-12-19. PMID: 21291525; PMCID: PMC3037317.
Comparative cardiopulmonary effects of size-fractionated airborne particulate matter
Amatullah H, North ML, Akhtar US, Rastogi N, Urch B, Silverman FS, Chow CW, Evans GJ, Scott JA. Inhal Toxicol. 2012 Feb;24(3):161-71. doi: 10.3109/08958378.2011.650235. Epub 2012 Feb 23. PMID: 22356274.
Spleen tyrosine kinase inhibition attenuates airway hyperresponsiveness and pollution-induced enhanced airway response in a chronic mouse model of asthma
Penton PC, Wang X, Amatullah H, Cooper J, Godri K, North ML, Khanna N, Scott JA, Chow CW. J Allergy Clin Immunol. 2013 Feb;131(2):512-20.e1-10. doi: 10.1016/j.jaci.2012.07.039. Epub 2012 Sep 13. PMID: 22981792.
Comparative genomics reveal that host-innate immune responses influence the clinical prevalence of Legionella pneumophila serogroups
Khan MA, Knox N, Prashar A, Alexander D, Abdel-Nour M, Duncan C, Tang P, Amatullah H, Dos Santos CC, Tijet N, Low DE, Pourcel C, Van Domselaar G, Terebiznik M, Ensminger AW, Guyard C. PLoS One. 2013 Jun 27;8(6):e67298. doi: 10.1371/journal.pone.0067298. PMID: 23826259; PMCID: PMC3694923.
ATF3 protects pulmonary resident cells from acute and ventilator-induced lung injury by preventing Nrf2 degradation
Shan Y, Akram A, Amatullah H, Zhou DY, Gali PL, Maron-Gutierrez T, González-López A, Zhou L, Rocco PR, Hwang D, Albaiceta GM, Haitsma JJ, dos Santos CC. Antioxid Redox Signal. 2015 Mar 10;22(8):651-68. doi: 10.1089/ars.2014.5987. Epub 2015 Jan 19. PMID: 25401197; PMCID: PMC4346377.
Maintenance of macrophage transcriptional programs and intestinal homeostasis by epigenetic reader SP140
Mehta S, Cronkite DA, Basavappa M, Saunders TL, Adiliaghdam F, Amatullah H, Morrison SA, Pagan JD, Anthony RM, Tonnerre P, Lauer GM, Lee JC, Digumarthi S, Pantano L, Ho Sui SJ, Ji F, Sadreyev R, Zhou C, Mullen AC, Kumar V, Li Y, Wijmenga C, Xavier RJ, Means TK, Jeffrey KL. Sci Immunol. 2017 Mar 3;2(9):eaag3160. doi: 10.1126/sciimmunol.aag3160. Epub 2017 Mar 3. PMID: 28783698; PMCID: PMC5549562.
DJ-1/PARK7 impairs bacterial clearance in sepsis
Amatullah H, Shan Y, Beauchamp BL, Gali PL, Gupta S, Maron-Gutierrez T, Speck ER, Fox-Robichaud AE, Tsang JL, Mei SH, Mak TW, Rocco PR, Semple JW, Zhang H, Hu P, Marshall JC, Stewart DJ, Harper ME, Liaw PC, Liles WC, Dos Santos CC; Canadian Critical Care Translational Biology Group. Am J Respir Crit Care Med. 2017 Apr 1;195(7):889-905. doi: 10.1164/rccm.201604-0730OC. PMID: 27735193.
Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells
Frodermann V, Rohde D, Courties G, Severe N, Schloss MJ, Amatullah H, McAlpine CS, Cremer S, Hoyer FF, Ji F, van Koeverden ID, Herisson F, Honold L, Masson GS, Zhang S, Grune J, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Lee IH, Gustafsson K, Pasterkamp G, de Jager SCA, Sadreyev RI, MacFadyen J, Libby P, Ridker P, Scadden DT, Naxerova K, Jeffrey KL, Swirski FK, Nahrendorf M. Nat Med. 2019 Nov;25(11):1761-1771. doi: 10.1038/s41591-019-0633-x. Epub 2019 Nov 7. PMID: 31700184; PMCID: PMC6858591.
Mesenchymal stromal/stem cells modulate response to experimental sepsis-induced lung injury via regulation of miR-27a-5p in recipient mice
Younes N, Zhou L, Amatullah H, Mei SHJ, Herrero R, Lorente JA, Stewart DJ, Marsden P, Liles WC, Hu P, Dos Santos CC. Thorax. 2020 Jul;75(7):556-567. doi: 10.1136/thoraxjnl-2019-213561. Epub 2020 Jun 16. PMID: 32546573; PMCID: PMC7361025.
Epigenome-metabolome-microbiome axis in health and IBD
Amatullah H, Jeffrey KL. Curr Opin Microbiol. 2020 Aug;56:97-108. doi: 10.1016/j.mib.2020.08.005. Epub 2020 Sep 10. PMID: 32920333; PMCID: PMC8270075.
Protective function of DJ-1/PARK7 in lipopolysaccharide and ventilator-induced acute lung injury
Amatullah H, Maron-Gutierrez T, Shan Y, Gupta S, Tsoporis JN, Varkouhi AK, Teixeira Monteiro AP, He X, Yin J, Marshall JC, Rocco PRM, Zhang H, Kuebler WM, Dos Santos CC. Redox Biol. 2021 Jan;38:101796. doi: 10.1016/j.redox.2020.101796. Epub 2020 Nov 17. PMID: 33246293; PMCID: PMC7695876.
Immunophenotypic characterization and therapeutics effects of human bone marrow- and umbilical cord-derived mesenchymal stromal cells in an experimental model of sepsis
Varkouhi AK, He X, Teixeira Monteiro AP, Amatullah H, Tsoporis JN, Gupta S, Ektesabi AM, Mei SHJ, Stewart DJ, Keating A, Dos Santos CC. Exp Cell Res. 2021 Feb 15;399(2):112473. doi: 10.1016/j.yexcr.2021.112473. Epub 2021 Jan 8. PMID: 33428902.
Cytoprotective mechanisms of DJ-1: Implications in cardiac pathophysiology
Tsoporis JN, Drosatos IA, Gupta S, Amatullah H, Izhar S, Dos Santos CC, Salpeas V, Rigopoulos AG, Toumpoulis IK, Triantafyllis AS, Sakadakis E, Kavantzas N, Marshall JC, Rizos IK, Parker TG. Molecules. 2021 Jun 22;26(13):3795. doi: 10.3390/molecules26133795. PMID: 34206441; PMCID: PMC8270312.
Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury
Dos Santos CC, Amatullah H, Vaswani CM, Maron-Gutierrez T, Kim M, Mei SHJ, Szaszi K, Monteiro APT, Varkouhi AK, Herreroz R, Lorente JA, Tsoporis JN, Gupta S, Ektesabi A, Kavantzas N, Salpeas V, Marshall JC, Rocco PRM, Marsden PA, Weiss DJ, Stewart DJ, Hu P, Liles WC. Eur Respir J. 2022 Jan 6;59(1):2004216. doi: 10.1183/13993003.04216-2020. Erratum in: Eur Respir J. 2023 Nov 9;62(5):2054216. doi: 10.1183/13993003.54216-2020. PMID: 34112731.
One genome, many cell states: Epigenetic control of innate immunity
Fraschilla I, Amatullah H, Jeffrey KL. Curr Opin Immunol. 2022 Apr;75:102173. doi: 10.1016/j.coi.2022.102173. Epub 2022 Apr 8. PMID: 35405493; PMCID: PMC9081230.
DJ-1 binds to rubicon to impair LC3-associated phagocytosis
Tsoporis JN, Amatullah H, Gupta S, Izhar S, Ektesabi AM, Vaswani CM, Desjardins JF, Kabir G, Teixera Monteiro AP, Varkouhi AK, Kavantzas N, Salpeas V, Rizos I, Marshall JC, Parker TG, Leong-Poi H, Dos Santos CC. Antioxidants (Basel). 2023 Feb 24;12(3):561. doi: 10.3390/antiox12030561. PMID: 36978809; PMCID: PMC10045744.
Epigenetic reader SP140 loss of function drives Crohn's disease due to uncontrolled macrophage topoisomerases
Amatullah H, Fraschilla I, Digumarthi S, Huang J, Adiliaghdam F, Bonilla G, Wong LP, Rivard ME, Beauchamp C, Mercier V, Goyette P, Sadreyev RI, Anthony RM, Rioux JD, Jeffrey KL. Cell. 2022 Aug 18;185(17):3232-3247.e18. doi: 10.1016/j.cell.2022.06.048. Epub 2022 Aug 10. PMID: 35952671; PMCID: PMC9442451.
Immune chromatin reader SP140 regulates microbiota and risk for inflammatory bowel disease
Fraschilla I, Amatullah H, Rahman RU, Jeffrey KL. Cell Host Microbe. 2022 Oct 12;30(10):1370-1381.e5. doi: 10.1016/j.chom.2022.08.018. Epub 2022 Sep 20. PMID: 36130593; PMCID: PMC10266544.
Human enteric viruses autonomously shape inflammatory bowel disease phenotype through divergent innate immunomodulation
Adiliaghdam F, Amatullah H, Digumarthi S, Saunders TL, Rahman RU, Wong LP, Sadreyev R, Droit L, Paquette J, Goyette P, Rioux JD, Hodin R, Mihindukulasuriya KA, Handley SA, Jeffrey KL. Sci Immunol. 2022 Apr 8;7(70). doi: 10.1126/sciimmunol.abn6660. Epub 2022 Apr 8. PMID: 35394816; PMCID: PMC9416881.
Sleep exerts lasting effects on hematopoietic stem cell function and diversity.
McAlpine CS, Kiss MG, Zuraikat FM, Cheek D, Schiroli G, Amatullah H, Huynh P, Bhatti MZ, Wong LP, Yates AG, Poller WC, Mindur JE, Chan CT, Janssen H, Downey J, Singh S, Sadreyev RI, Nahrendorf M, Jeffrey KL, Scadden DT, Naxerova K, St-Onge MP, Swirski FK. J Exp Med. 2022 Nov 7;219(11). doi: 10.1084/jem.20220081. Epub 2022 Sep 21. PubMed PMID: 36129517; PubMed Central PMCID: PMC9499822.
DJ-1 deficiency protects against sepsis-induced myocardial depression
Tsoporis JN, Amatullah H, Gupta S, Izhar S, Ektesabi AM, Vaswani CM, Desjardins JF, Kabir G, Teixera Monteiro AP, Varkouhi AK, Kavantzas N, Salpeas V, Rizos I, Marshall JC, Parker TG, Leong-Poi H, Dos Santos CC. Antioxidants (Basel). 2023 Feb 24;12(3). doi: 10.3390/antiox12030561. PubMed PMID: 36978809; PubMed Central PMCID: PMC10045744.
NET formation is a default epigenetic program controlled by PAD4 in apoptotic neutrophils.
Zhu YP, Speir M, Tan Z, Lee JC, Nowell CJ, Chen AA, Amatullah H, Salinger AJ, Huang CJ, Wu G, Peng W, Askari K, Griffis E, Ghassemian M, Santini J, Gerlic M, Kiosses WB, Catz SD, Hoffman HM, Greco KF, Weller E, Thompson PR, Wong LP, Sadreyev R, Jeffrey KL, Croker BA. Sci Adv. 2023 Dec 22;9(51):eadj1397. doi: 10.1126/sciadv.adj1397. Epub 2023 Dec 20. PubMed PMID: 38117877; PubMed Central PMCID: PMC10732518.